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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10254531 B1

PDFFull Text
Date of Patent:
Apr. 09, 2019

Filed:

Aug. 01, 2018

Method for observing a sample by lens-free imaging

Applicant:

Commissariat a L'energie Atomique ET Aux Energies Alternatives, Paris, FR;

Inventors:

Sophie Morel, Douai, FR;

Cedric Allier, Grenoble, FR;

Assignee:

Commissariat A l'Energie Atomique et aux Energies Alternatives, Paris, FR;

Attorney:

Oblon, McClelland, Maier & Neustadt, L.L.P.

Primary Examiner:

Hwa Andrew Lee

Int. Cl.
CPC ...
G02B 21/36 (2006.01); G03H 1/00 (2006.01); G01N 21/25 (2006.01); G01N 33/483 (2006.01); G02B 21/33 (2006.01); G03H 1/04 (2006.01); G03H 1/08 (2006.01); G01N 21/45 (2006.01); G01B 9/021 (2006.01); G01N 15/10 (2006.01); G01N 15/14 (2006.01);
U.S. Cl.
CPC ...
G02B 21/367 (2013.01); G01N 21/255 (2013.01); G01N 21/455 (2013.01); G01N 33/4833 (2013.01); G02B 21/33 (2013.01); G03H 1/0005 (2013.01); G03H 1/0443 (2013.01); G03H 1/0465 (2013.01); G03H 1/0866 (2013.01); G01B 9/021 (2013.01); G01N 15/1463 (2013.01); G01N 2015/1006 (2013.01); G01N 2201/0627 (2013.01); G03H 2001/005 (2013.01); G03H 2001/0447 (2013.01); G03H 2001/0454 (2013.01); G03H 2001/0471 (2013.01);
Abstract

The invention relates to a method for observing a sample, in particular an anatomopathological slide formed from a thin thickness of a sampled biological tissue. It includes a step of illuminating the sample with a light source and acquiring, with an image sensor, an image representing the light transmitted by the sample. The image undergoes holographic reconstruction, so as to obtain a representation, in the plane of the sample, of the light wave transmitted by the latter. The method includes applying an impregnating fluid to the sample, such that the sample is impregnated with said impregnating liquid, said impregnating liquid having a refractive index strictly higher than 1.

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