The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 09, 2019
Filed:
Jul. 02, 2015
Applicant:
Csl Behring Lengnau Ag, Lengnau BE, CH;
Inventors:
Michael Wilson, Victoria, AU;
Steve Dower, Victoria, AU;
Dallas Hartman, Victoria, AU;
Mathew Hardy, Victoria, AU;
Assignee:
CSL Behring Lengnau AG, Lengnau BE, CH;
Primary Examiner:
Int. Cl.
CPC ...
A61P 7/04 (2006.01); A61K 38/00 (2006.01); A61K 38/36 (2006.01); A61K 38/37 (2006.01); C07K 14/755 (2006.01); C07K 14/765 (2006.01);
U.S. Cl.
CPC ...
C07K 14/755 (2013.01); A61K 38/36 (2013.01); A61K 38/37 (2013.01); A61P 7/04 (2018.01); C07K 14/765 (2013.01); A61K 38/00 (2013.01); C07K 2319/31 (2013.01);
Abstract
The present invention provides a modified polypeptide which binds Factor VIII. The modified polypeptide comprises a sequence as shown in SEQ ID NO:3 in which the sequence comprises at least a modification at position 1 or 3 such that the modified polypeptide binds to Factor VIII with an off rate at least 5 fold lower than a reference polypeptide comprising an unmodified SEQ ID NO:3.