The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 09, 2019
Filed:
Dec. 21, 2016
Applicant:
Ambrx, Inc., La Jolla, CA (US);
Inventors:
Vadim Kraynov, San Diego, CA (US);
Nick Knudsen, Escondito, CA (US);
Amha Hewet, Chula Vista, CA (US);
Kristine De Dios, San Diego, CA (US);
Jason Pinkstaff, Encinitas, CA (US);
Lorraine Sullivan, San Diego, CA (US);
Assignee:
AMBRX, INC., La Jolla, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/18 (2006.01); C07K 14/64 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/64 (2013.01); A61K 38/00 (2013.01);
Abstract
Therapeutic uses of modified relaxin polypeptides for the treatment of cardiovascular disease, treatment of heart failure, and decreasing fibrotic disorders are provided. Exemplary embodiments provide for the use of relaxin polypeptides which include one or more amino acid substitutions with natural or non-naturally encoded amino acids, and/or linkage to a water-soluble polymer, such as polyethylene glycol.