The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 09, 2019
Filed:
Nov. 21, 2014
Jiangsu Tasly Diyi Pharmaceutical Co., Ltd., Huai'an, Jiangsu, CN;
Wei Zhou, Tianjin, CN;
Yunrong Jing, Tianjin, CN;
Yongfeng Wang, Tianjin, CN;
Guocheng Wang, Tianjin, CN;
Jiangsu Tasly Diyi Pharmaceutical Co., Ltd., Huai'an, Jiangsu, CN;
Abstract
The present invention provides taxanes compounds with a formula (I) or formula (II) structure, a method for preparing the compounds, as well as the use of the compositions containing the compounds, pharmaceutically acceptable salts and solvates thereof as active ingredients in manufacturing oral antitumor medicaments, In formula (I), Ris —COR, —COORor —CONRR; Ris a C1-C6 alkyl, a C1-C6 alkenyl, a substituted hydrocarbon group, a heterocyclic group, an aromatic group or a substituted aromatic group; Ris —OR, —OCOOR, —OCOSRor —OCONRR; Ris —OR, —OCOOR, —OCOSR, —OCONRRor H; wherein, Ris a C1-C6 alkyl, a C1-C6 alkenyl, a C1-C6 alkynyl, a substituted hydrocarbon group, an aromatic group or a heterocyclic group; Rand Rare respectively hydrogen, a hydrocarbon group, a substituted hydrocarbon group or a heterocyclic group. In formula (II), Ris —CORor —COOR; Ris an aromatic group; Ris —OR; wherein, Ris a C1-C6 alkyl, a C1-C6 alkenyl, a C1-C6 alkynyl, a substituted hydrocarbon group, an aromatic group or a heterocyclic group.