The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 09, 2019
Filed:
Jun. 01, 2012
Young Eun Woo, Daejeon, KR;
Myung Hyun Jang, Seoul, KR;
Young Jin Park, Suwon-si, KR;
Young Kyung Park, Hwaseong-si, KR;
Chang Ki Lim, Hwaseong-si, KR;
SE Chang Kwon, Seoul, KR;
Young Eun Woo, Daejeon, KR;
Myung Hyun Jang, Seoul, KR;
Young Jin Park, Suwon-si, KR;
Young Kyung Park, Hwaseong-si, KR;
Chang Ki Lim, Hwaseong-si, KR;
Se Chang Kwon, Seoul, KR;
HANMI SCIENCE CO., LTD., Hwaseong-si, KR;
Abstract
The present invention relates to a composition for the prevention or treatment of diabetes comprising a long-acting insulin conjugate and a long-acting insulinotropic peptide conjugate, and a therapeutic method for the treatment of diabetes, and more particularly, concurrent administration of the long-acting insulin conjugate and the long-acting insulinotropic peptide conjugate inhibits weight gain caused by insulin treatment, and vomiting and nausea caused by insulinotropic peptide treatment, and reduces the required dose of insulin, thereby remarkably improving drug compliance. Moreover, each of the long-acting insulin conjugate and the long-acting insulinotropic peptide conjugate of the present invention is prepared by linking insulin or insulinotropic peptide with an immunoglobulin Fc region via a non-peptidyl linker, thereby showing improved in-vivo duration of efficacy and stability.