The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 09, 2019
Filed:
Oct. 20, 2017
Icahn School of Medicine AT Mount Sinai, New York, NY (US);
Memorial Sloan Kettering Cancer Center, New York, NY (US);
Peter Palese, New York, NY (US);
Adolfo Garcia-Sastre, New York, NY (US);
Dmitriy Zamarin, New York, NY (US);
Jedd D. Wolchok, New York, NY (US);
Icahn School of Medicine at Mount Sinai, New York, NY (US);
Memorial Sloan Kettering Cancer Center, New York, NY (US);
Abstract
Described herein are chimeric Newcastle disease viruses engineered to express an agonist of a co-stimulatory signal of an immune cell and compositions comprising such viruses. Also described herein are chimeric Newcastle disease viruses engineered to express an antagonist of an inhibitory signal of an immune cell and compositions comprising such viruses. The chimeric Newcastle disease viruses and compositions are useful in the treatment of cancer. In addition, described herein are methods for treating cancer comprising administering Newcastle disease viruses in combination with an agonist of a co-stimulatory signal of an immune and/or an antagonist of an inhibitory signal of an immune cell.