The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 09, 2019
Filed:
Jun. 24, 2015
Applicant:
Mie University, Tsu-shi, JP;
Inventors:
Assignee:
MIE UNIVERSITY, Tsu-Shi, JP;
Primary Examiner:
Int. Cl.
CPC ...
A01K 67/027 (2006.01); G01N 33/00 (2006.01); C12N 15/00 (2006.01); C12N 15/09 (2006.01); G01N 33/53 (2006.01); C07K 14/495 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
A01K 67/0278 (2013.01); C07K 14/495 (2013.01); C12N 15/09 (2013.01); G01N 33/53 (2013.01); G01N 33/6863 (2013.01); A01K 2207/15 (2013.01); A01K 2217/072 (2013.01); A01K 2227/105 (2013.01); A01K 2267/035 (2013.01); A01K 2267/0368 (2013.01); C12N 2830/008 (2013.01);
Abstract
A transgenic mouse has a genome that includes the entire gene region of human transforming growth factor beta-1 (human TGFβ1) located downstream of a mouse Podocin promoter such that expression of the human TGFβ1 is controlled by the mouse Podocin promoter. The human TGFβ1 contains 7 exons and 6 introns, the human TGFβ1 is expressed in a kidney of the mouse as non-active TGFβ1 and becomes active TGFβ1 extracellularly, and the transgenic mouse spontaneously develops renal fibrosis.