The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 02, 2019

Filed:

Sep. 09, 2014
Applicant:

Chu Sainte-justine, Montréal, CA;

Inventors:

Alain Moreau, Montréal, CA;

Marie-Yvonne Akoume Ndong, Montréal, CA;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/19 (2006.01); A61F 5/02 (2006.01); A61K 33/04 (2006.01); A61K 31/713 (2006.01); A61K 31/4045 (2006.01); G01N 33/68 (2006.01); A61K 45/06 (2006.01); C12N 15/113 (2010.01); G01N 33/487 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6893 (2013.01); A61F 5/02 (2013.01); A61F 5/026 (2013.01); A61K 31/4045 (2013.01); A61K 31/713 (2013.01); A61K 33/04 (2013.01); A61K 38/19 (2013.01); A61K 45/06 (2013.01); C12N 15/1138 (2013.01); G01N 33/48728 (2013.01); C12N 2310/14 (2013.01); C12N 2320/30 (2013.01); G01N 2333/47 (2013.01); G01N 2333/726 (2013.01); G01N 2800/10 (2013.01); G01N 2800/50 (2013.01); G01N 2800/52 (2013.01);
Abstract

A method of classifying a subject having idiopathic scoliosis (IS) or at risk of developing IS comprising: determining the cellular response to Gi stimulation in a cell sample from the subject in the presence of OPN; determining the cellular response to Gi stimulation in a cell sample from the subject in the absence of OPN; and comparing the cellular response obtained in the presence of OPN with the cellular response obtained in the absence of OPN, whereby the comparing step enables the classification of the subject into one IS functional group. Also provided is the use of the foregoing method to classify borderline subjects and kits for applying the methods.


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