The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 02, 2019
Filed:
Dec. 05, 2016
Applicant:
Case Western Reserve University, Cleveland, OH (US);
Inventors:
Chung-Chiun Liu, Cleveland Heights, OH (US);
Laurie Dudik, South Euclid, OH (US);
Po-Yuam Lin, Cleveland, OH (US);
Assignee:
CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH (US);
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/533 (2006.01); H01M 14/00 (2006.01); G01N 27/327 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/533 (2013.01); G01N 27/3272 (2013.01); H01M 14/00 (2013.01); G01N 2800/342 (2013.01); G01N 2800/7028 (2013.01);
Abstract
A detection system for determining alpha-methylacyl-CoA (AMACR) levels in a bodily sample includes at least one reaction solution for generating HOupon combination with AMACR in the bodily sample and a biosensor for determining a level of generated HO. The reaction solution includes a (2R)-2-methylacyl-CoA epimer that can be chirally inverted by AMACR to a (2S)-2-methylacyl-CoA epimer and an enzyme that carries out beta oxidation with the (2S)-2-methylacyl-CoA epimer to generate hydrogen peroxide (HO).