The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 02, 2019
Filed:
Jun. 06, 2016
Applicant:
Case Western Reserve University, Cleveland, OH (US);
Inventors:
Ryan R. Geyer, Cleveland, OH (US);
Pan Zhao, Cleveland, OH (US);
Mark D. Parker, Cleveland, OH (US);
Walter F. Boron, Cleveland, OH (US);
Assignee:
CASE WESTERN UNIVERSITY, Cleveland, OH (US);
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/527 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/527 (2013.01); C12Y 402/01001 (2013.01); G01N 2333/988 (2013.01);
Abstract
A method and assay for using carbonic anhydrase (CA), particularly CA-I or CA-II, as a biomarker of hemolysis. The method and assay detect hemolysis by determining a percentage erythrocyte hemolysis in a specimen or sample of blood based upon quantification of carbonic anhydrase present in the extracellular portion of the blood. The method and test serve to optimize therapeutic efficacy for treatments of hemolysis.