The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 02, 2019
Filed:
Nov. 17, 2017
The Regents of the University of California, Oakland, CA (US);
Dennis Clegg, Ventura, CA (US);
Sherry T. Hikita, Santa Barbara, CA (US);
Lincoln V. Johnson, Santa Barbara, CA (US);
Liane Miller, San Francisco, CA (US);
Marlene Tsie, Santa Barbara, CA (US);
Chelsea D. Presbrey, Flagstaff, AZ (US);
Lisa R. Conti, Goleta, CA (US);
Michelle A. Maloney, Santa Barbara, CA (US);
David R. Hinton, Venice Beach, CA (US);
Qirui Hu, Santa Barbara, CA (US);
The Regents of the University of California, Oakland, CA (US);
University of Southern California, Los Angeles, CA (US);
Abstract
The production of high quality retinal pigmented epithelium (RPE) cells is necessary for research and potential therapeutic uses. Especially desirable are methods for the production of RPE cells using xeno-free culture conditions. Disclosed herein are novel methods for the production of RPE cells from pluripotent cells with high yields, including xeno-free production methods. Also provided are methods of efficiently isolating RPE cells from cultures containing heterogeneous cell types, allowing for substantially pure RPE cell cultures to be established. Additionally, novel methods for the cryopreservation of RPE cells are provided.