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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10246503 B1

PDFFull Text
Date of Patent:
Apr. 02, 2019

Filed:

Dec. 19, 2013

Method of improving the pharmacokinetic profile of a therapeutic polypeptide and the use thereof

Applicant:

Beijing Anxinhuaide Biotech. Co., Ltd, Beijing, CN;

Inventors:

Xinguo Qian, Beijing, CN;

Wei Hong, Shijiazhuang, CN;

Xiaoyu Ma, Beijing, CN;

Assignee:

BEIJING ANXINHUAIDE BIOTECH. CO., LTD., Beijing, CN;

Attorneys:

Christensen O'Connor

Johnson Kindness PLLC

Primary Examiner:

Gyan Chandra

Int. Cl.
CPC ...
C07K 14/605 (2006.01); A61K 38/26 (2006.01); C07K 14/635 (2006.01); C07K 14/705 (2006.01); C07K 14/715 (2006.01); C07K 14/78 (2006.01); C07K 14/71 (2006.01); A61K 38/17 (2006.01); A61K 38/18 (2006.01); A61K 38/19 (2006.01); A61K 38/21 (2006.01); A61K 38/27 (2006.01); A61K 38/29 (2006.01);
U.S. Cl.
CPC ...
C07K 14/605 (2013.01); A61K 38/26 (2013.01); C07K 14/635 (2013.01); C07K 14/70578 (2013.01); C07K 14/71 (2013.01); C07K 14/7151 (2013.01); C07K 14/7156 (2013.01); C07K 14/78 (2013.01); A61K 38/179 (2013.01); A61K 38/1816 (2013.01); A61K 38/193 (2013.01); A61K 38/21 (2013.01); A61K 38/27 (2013.01); A61K 38/29 (2013.01); C07K 2319/31 (2013.01);
Abstract

The present invention provides a fusion protein comprising a therapeutic polypeptide fused to one or more flexible unstructured polypeptides and a trimeric scaffold protein. The flexible unstructured polypeptide sequence within the fusion protein is exhibited as one or more pCloud sequences derived from human fibrinogen alpha chain, and may be flanked by a proteinous connecting moiety of human origin. Also provided are pharmaceutical compositions comprising the fusion protein, nucleic acid molecules encoding the fusion protein, vectors containing the nucleic acids, host cells transformed with the vectors, and methods of making the fusion proteins of the invention, and use thereof.

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