The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 02, 2019
Filed:
Jun. 15, 2015
Applicant:
University of Cape Town, Cape Town, ZA;
Inventors:
Assignee:
The University of Cape Town, Cape Town, ZA;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/515 (2006.01); C07K 16/28 (2006.01); A61K 38/18 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/515 (2013.01); A61K 38/1891 (2013.01); C07K 16/28 (2013.01); C07K 16/283 (2013.01); A61K 38/00 (2013.01); C07K 2317/622 (2013.01); C07K 2319/00 (2013.01); C07K 2319/74 (2013.01);
Abstract
The technology provided herein relates to novel human cytolytic fusion proteins (hCFPs) suitable to induce apoptosis in human cells comprising a target cell-specific binding component and a human effector domain, wherein the binding component comprises an antibody or an antibody fragment with an antigen-binding site for binding to the cellular surface receptor CD64 and the effector domain comprises a variant of wild type human angiogenin (Ang) or a functional fragment thereof; to nucleic acid molecules encoding said recombinant hCFPs, vectors and host cells containing said nucleic acids and methods for preparation and producing these hCFPs.