The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 02, 2019
Filed:
Aug. 14, 2015
Monash University, Clayton, Victoria, AU;
LA Trobe University, Bundoora, Victoria, AU;
Peptides International, Inc., Louisville, KY (US);
Baylor College of Medicine, Houston, TX (US);
Raymond S. Norton, Rosanna, AU;
Shih Chieh Chang, Singapore, SG;
Michael W. Pennington, Shelbyville, KY (US);
Christine Beeton, Pearland, TX (US);
Brian J. Smith, Sunbury, AU;
LA TROBE UNIVERSITY, , AU;
MONASH UNIVERSITY, , AU;
BAYLOR COLLEGE OF MEDICINE, Houston, TX (US);
PEPTIDES INTERNATIONAL, INC., Louisville, KY (US);
Abstract
Novel analogues of the sea anemonetoxin ShK, and their use as, for example, therapeutic agents for treating autoimmune diseases are disclosed. The analogues comprise a ShK toxin polypeptide and an N-terminal extension comprising an amino acid sequence according to formula (I): wherein Xis D, E or other negatively-charged amino acid or derivative thereof, Xis E, I, L, S, V, W or a tryptophan derivative, Xis any amino acid, Xis any amino acid, a is absent or a first additional moiety, and b is absent or a second additional moiety.a-XXXX-b(SEQ ID NO: 3)  (I)