The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 02, 2019

Filed:

Sep. 29, 2016
Applicant:

Bristol-myers Squibb Company, Princeton, NJ (US);

Inventors:

Joanne J. Bronson, Durham, CT (US);

Ling Chen, Doylestown, PA (US);

Jonathan L. Ditta, Meriden, CT (US);

Carolyn Diane Dzierba, Middletown, CT (US);

Prasada Rao Jalagam, Bangalore, IN;

Guanglin Luo, Madison, CT (US);

John E. Macor, Washington Crossing, PA (US);

Tarun Kumar Maishal, Bangalore, IN;

Susheel Jethanand Nara, Mumbai, IN;

Ramkumar Rajamani, Acton, MA (US);

Ramesh Kumar Sistla, Bangalore, IN;

Soodamani Thangavel, Hosur, IN;

Assignees:

Bristol-Myers Squibb Company, Princeton, NJ (US);

Syngene International Limited, Bangalore, Karnataka, IN;

Bristol-Myers Squibb Company, Princeton, NJ (US);

Attorney:
Int. Cl.
CPC ...
C07D 401/04 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 403/14 (2006.01); C07D 237/08 (2006.01); C07D 239/26 (2006.01); C07D 213/34 (2006.01); A61K 31/50 (2006.01); A61K 31/51 (2006.01); A61K 31/505 (2006.01); A61K 31/506 (2006.01); A61K 31/44 (2006.01); A61K 31/4427 (2006.01); A61P 25/28 (2006.01); C07D 513/04 (2006.01); A61P 25/18 (2006.01); A61P 25/16 (2006.01); C07D 213/74 (2006.01);
U.S. Cl.
CPC ...
C07D 513/04 (2013.01); A61K 31/44 (2013.01); A61K 31/4427 (2013.01); A61K 31/50 (2013.01); A61K 31/505 (2013.01); A61K 31/506 (2013.01); A61K 31/51 (2013.01); A61P 25/16 (2018.01); A61P 25/18 (2018.01); A61P 25/28 (2018.01); C07D 213/74 (2013.01); C07D 237/08 (2013.01); C07D 239/26 (2013.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 403/14 (2013.01);
Abstract

The present disclosure is directed to biaryl compounds of formula (I) which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds and their use for treating e.g. pain, Alzheimer's disease, Parkinson's disease and schizophrenia.


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