The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 02, 2019
Filed:
Sep. 08, 2015
The Regents of the University of Michigan, Ann Arbor, MI (US);
Kura Oncology, Inc, La Jolla, CA (US);
Jolanta Grembecka, Ann Arbor, MI (US);
Tomasz Cierpicki, Ann Arbor, MI (US);
Dmitry Borkin, Ann Arbor, MI (US);
Jonathan Pollock, Ann Arbor, MI (US);
Hongzhi Miao, Ann Arbor, MI (US);
Duxin Sun, Ann Arbor, MI (US);
Liansheng Li, La Jolla, CA (US);
Tao Wu, La Jolla, CA (US);
Jun Feng, La Jolla, CA (US);
Pingda Ren, La Jolla, CA (US);
Yi Liu, La Jolla, CA (US);
THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US);
KURA ONCOLOGY, INC., La Jolla, CA (US);
Abstract
The present disclosure provides compounds and methods for inhibiting the interaction of menin with its upstream or downstream signaling molecules including but not limited to MLL1, MLL2 and MLL-fusion oncoproteins. Compounds of the disclosure may be used in methods for the treatment of a wide variety of cancers and other diseases associated with one or more of MLL1, MLL2, MLL fusion proteins, and menin.