The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 02, 2019
Filed:
Dec. 16, 2016
Applicant:
Dompé Farmaceutici S.p.a., Milan, IT;
Inventors:
Assignee:
DOMPÉ FARMACEUTICI S.P.A., Milan, IT;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61P 11/00 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); C07D 417/06 (2006.01);
U.S. Cl.
CPC ...
C07D 417/06 (2013.01); A61P 11/00 (2018.01); A61P 29/00 (2018.01); A61P 35/00 (2018.01);
Abstract
The invention relates to compounds acting as antagonists of Transient Receptor Potential cation channel subfamily M member 8 (TRPM8), and having formula (I): Said compounds are useful in the treatment of diseases associated with activity of TRPM8 such as pain, ischaemia, neurodegeneration, stroke, psychiatric disorders, itch, irritable bowel diseases, cold-induced and/or exacerbated-respiratory disorders, urological disorders, corneal disorders associated to disturbances in the production of the tears and/or altered blinking such as epiphora and dry eye disease.