The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 02, 2019

Filed:

Jan. 08, 2015
Applicant:

Kyungpook National University Industry-academic Cooperation Foundation, Daegu, KR;

Inventors:

Tae-Jeong Kim, Gyeongsan-si, KR;

Yong Min Chang, Daegu, KR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 257/02 (2006.01); A61K 49/06 (2006.01); A61K 49/08 (2006.01); A61K 49/10 (2006.01); C07F 5/00 (2006.01);
U.S. Cl.
CPC ...
A61K 49/108 (2013.01); A61K 49/106 (2013.01); C07D 257/02 (2013.01); C07F 5/00 (2013.01);
Abstract

The present disclosure relates to a magnetic resonance imaging (MRI) contrast agent containing a gadolinium complex, and more specically, to a DO3A-tranexamic acid compound having a structure of a chemical formula 1, or an ester compound thereof, and gadolinium complexes thereof. The DO3A-tranexamic acid compound or the ester compound thereof may be used to prepare gadolinium complexes. The gadolinium complexes exhibit thermodynamic and kinetic stabilities, and show the relaxation rate equal to that of the clinical contrast agent which is currently commercially available. Therefore, the gadolinium complexes can be widely used as an MRI contrast agent.


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