The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 26, 2019
Filed:
May. 28, 2014
Ventana Medical Systems, Inc., Tucson, AZ (US);
Joerg Bredno, San Francisco, CA (US);
Lou Dietz, Mountain View, CA (US);
Jim F. Martin, Mountain View, CA (US);
Ventana Medical Systems, Inc., Tucson, AZ (US);
Abstract
The subject disclosure presents systems and methods for separating colors in an image by automatically and adaptively adjusting reference vectors based on information specific to the assay being imaged, resulting in an optimized unmixing process that provides stain information that is physically and physiologically plausible. The reference vectors are optimized iteratively, based on minimizing non-negative color contributions, background contributions, high-frequencies in color channels specific to background or unwanted fluorescence, signals from known immunohistochemical markers, and pairs of stains known to carry physiologically independent information. Adjustments to the reference vectors may be allowed within a range that is predetermined based on measuring colors from multiple input images.