The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 26, 2019
Filed:
Dec. 08, 2014
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Robert H. Pierce, San Francisco, CA (US);
Jennifer H. Yearley, Palo Alto, CA (US);
Scott P. Turner, Sunnyvale, CA (US);
Belma Dogdas, Secaucus, NJ (US);
Ansuman Bagchi, Plainsboro, NJ (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
The present disclosure describes an IHC assay for detecting and quantifying spatially proximal pairs of PD-1-expressing cells (PD-1+ cells) and PD-Ligand-expressing cells (PD-L+ cells) in tumor tissue, and the use of the assay to generate proximity biomarkers that are predictive of which cancer patients are most likely to benefit from treatment with a PD-1 antagonist. The disclosure also provides methods for testing tumor samples for the proximity biomarkers, as well as methods for treating subjects with a PD-1 antagonist based on the test results.