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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10240138 B1

PDFFull Text
Date of Patent:
Mar. 26, 2019

Filed:

Jun. 11, 2009

Polypeptides that bind to and inhibit secretion from growth hormone secreting cells

Applicants:

Frederic Madec, Abingdon, GB;

Phil Lecane, Abingdon, GB;

Philip Marks, Abingdon, GB;

Keith Foster, Abingdon, GB;

Inventors:

Frederic Madec, Abingdon, GB;

Phil Lecane, Abingdon, GB;

Philip Marks, Abingdon, GB;

Keith Foster, Abingdon, GB;

Assignee:

IPSEN BIOINNOVATION LIMITED, Abingdon, Oxfordshire, unknown;

Attorneys:

Gene J. Yao

Barnes & Thornburg LLP

Primary Examiner:

Sheridan Swope

Int. Cl.
CPC ...
C12N 9/50 (2006.01); C12N 9/64 (2006.01); C07K 7/08 (2006.01); C07K 14/33 (2006.01); C07K 14/48 (2006.01); C07K 14/575 (2006.01); C07K 14/60 (2006.01); C07K 14/65 (2006.01); C07K 14/82 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/50 (2013.01); C07K 7/086 (2013.01); C07K 14/33 (2013.01); C07K 14/48 (2013.01); C07K 14/575 (2013.01); C07K 14/5759 (2013.01); C07K 14/57563 (2013.01); C07K 14/60 (2013.01); C07K 14/65 (2013.01); C07K 14/82 (2013.01); C12N 9/6489 (2013.01); A61K 38/00 (2013.01); C07K 2319/035 (2013.01); C07K 2319/06 (2013.01); C07K 2319/33 (2013.01); C07K 2319/50 (2013.01);
Abstract

The present invention relates to a method for suppressing or treating cancer, in particular to a method for suppressing or treating one or more of colorectal cancer, breast cancer, prostate cancer and/or lung cancer. The therapy employs use of a non-cytotoxic protease, which is targeted to a growth hormone-secreting cell such as to a pituitary cell. When so delivered, the protease is internalized and inhibits secretion/transmission of growth hormone from said cell. The present invention also relates to polypeptides and nucleic acids for use in said methods.

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