The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 26, 2019
Filed:
Jul. 20, 2018
Aptevo Research and Development Llc, Seattle, WA (US);
Alligator Bioscience Ab, Lund, SE;
David Bienvenue, Seattle, WA (US);
Gabriela Hernandez-Hoyos, Seattle, WA (US);
Lynda Misher, Seattle, WA (US);
Danielle Mitchell, Seattle, WA (US);
Peter Ellmark, Lund, SE;
Anna Sall, Lund, SE;
Christina Furebring, Lund, SE;
Laura von Schantz, Lund, SE;
Sara Fritzell, Lund, SE;
Laura Varas, Lund, SE;
Aptevo Research and Development, LLC, Seattle, WA (US);
Alligator Bioscience AB, Lund, SE;
Abstract
The present disclosure relates to protein molecules that specifically bind to 5T4 and/or 4-1BB. The molecules may have at least one humanized 5T4-binding or 4-1BB-binding domain. Such molecules are useful for the treatment of cancer. The protein molecule binding to 5T4 or 4-1BB may have a second binding domain that binds to another target. The molecules may bind both 5T4-expressing cells and a cell-surface molecule expressed by an effector cell to enhance effector cell activation, proliferation, survival and/or effector-cell mediated cytotoxicity. The disclosure also provides pharmaceutical compositions comprising the 5T4-binding or 4-1BB-binding polypeptide or protein molecules, nucleic acid molecules encoding these polypeptides and methods of making and using these molecules.