The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 26, 2019
Filed:
Apr. 18, 2017
Applicant:
Cem Corporation, Matthews, NC (US);
Inventor:
Jonathan M. Collins, Charlotte, NC (US);
Assignee:
CEM Corporation, Matthews, NC (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 1/04 (2006.01);
U.S. Cl.
CPC ...
C07K 1/04 (2013.01); C07K 1/045 (2013.01);
Abstract
An improvement of deprotection in solid phase peptide synthesis is disclosed. The method includes the steps of adding the deprotection composition in high concentration and small volume to the mixture of the coupling solution, the growing peptide chain, and any excess activated amino acid from the preceding coupling cycle; and without any draining step between the coupling step of the previous cycle and the addition of the deprotection composition for the successive cycle; and with the coupling solution at a temperature of at least 30° C.