The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 26, 2019
Filed:
Mar. 20, 2018
Keio University, Tokyo, JP;
National Institute of Advanced Industrial Science and Technology, Tokyo, JP;
The University of Tokyo, Tokyo, JP;
Koji Suzuki, Yokohama, JP;
Daniel Citterio, Yokohama, JP;
Ryo Nishihara, Yokohama, JP;
Sung-Bae Kim, Tsukuba, JP;
Moritoshi Sato, Tokyo, JP;
Takahiro Nakajima, Tokyo, JP;
KEIO UNIVERSITY, Tokyo, JP;
NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY, Tokyo, JP;
THE UNIVERSITY OF TOKYO, Tokyo, JP;
Abstract
There is provided a series of coelenterazine (CTZ) derivatives as a substrate with high luminescence intensity, which is optimal for maximum luminescence wavelengths at both 400 nm (blue-shifted RLuc luminescence system) and 500 nm (ALuc luminescence system) for bioassays which is more sensitive than known techniques. The novel CTZ derivatives are compounds in which a specific position(s) of the CTZ is/are substituted with a specific substituent(s) as shown, for example, by the Formula [I], and has a higher luminescence intensity than known CTZ derivatives in blue-shifted RLuc luminescence system or ALuc luminescence system.