The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 26, 2019
Filed:
Mar. 30, 2017
Applicant:
Valerion Therapeutics, Llc, Concord, MA (US);
Inventor:
Dustin D. Armstrong, Quincy, MA (US);
Assignee:
Valerion Therapeutics, LLC, Concord, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); A61K 47/68 (2017.01); A61K 31/7088 (2006.01); C07K 16/44 (2006.01); C12N 15/113 (2010.01); A61J 1/14 (2006.01); A61K 31/713 (2006.01); C07K 16/28 (2006.01); A61K 47/69 (2017.01);
U.S. Cl.
CPC ...
A61K 47/6807 (2017.08); A61J 1/14 (2013.01); A61K 31/7088 (2013.01); A61K 31/713 (2013.01); A61K 47/6849 (2017.08); A61K 47/6851 (2017.08); A61K 47/6901 (2017.08); C07K 16/28 (2013.01); C07K 16/44 (2013.01); C12N 15/1137 (2013.01); C12Y 207/11001 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01); C07K 2317/77 (2013.01); C12N 2310/11 (2013.01); C12N 2310/315 (2013.01); C12N 2310/322 (2013.01); C12N 2310/3231 (2013.01); C12N 2310/3233 (2013.01); C12N 2310/346 (2013.01); C12N 2310/3513 (2013.01);
Abstract
The disclosure provides novel conjugates comprising antisense oligonucleotides that hybridize to a DMPK transcript and a 3E10 antibody or binding fragment thereof. Also considered are these conjugates further comprising MBNL1 polypeptides. Methods of treating myotonic dystrophy using these conjugates and kits comprising these conjugates are also considered. Wherein the conjugates are suitable for delivery to muscle cells.