The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 26, 2019
Filed:
May. 06, 2014
Applicant:
Oklahoma Medical Research Foundation, Oklahoma City, OK (US);
Inventors:
Assignee:
OKLAHOMA MEDICAL RESEARCH FOUNDATION, Oklahoma City, OK (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); A61K 38/10 (2006.01); A61K 31/727 (2006.01); A61K 38/17 (2006.01); A61K 38/48 (2006.01); A61K 45/06 (2006.01); C07K 16/18 (2006.01); C07K 16/40 (2006.01); G01N 33/68 (2006.01); A61K 38/36 (2006.01); C07K 7/08 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/10 (2013.01); A61K 31/727 (2013.01); A61K 38/1709 (2013.01); A61K 38/36 (2013.01); A61K 38/4833 (2013.01); A61K 38/4846 (2013.01); A61K 38/4866 (2013.01); A61K 39/3955 (2013.01); A61K 45/06 (2013.01); C07K 7/08 (2013.01); C07K 16/18 (2013.01); C07K 16/40 (2013.01); C12Y 304/21005 (2013.01); C12Y 304/21006 (2013.01); G01N 33/6875 (2013.01); A61K 2039/505 (2013.01); C07K 2317/76 (2013.01); C12Y 304/21069 (2013.01);
Abstract
Hyper-inflammatory responses can lead to a variety of diseases including sepsis. It is now shown that extracellular histones released in response to inflammatory challenge are mediators contributing to endothelial dysfunction, organ failure and death during sepsis. As such, they can be targeted pharmacologically by inhibitors, as well as used as biomarkers for prognosis of sepsis and other diseases.