The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 26, 2019
Filed:
Jan. 25, 2013
Dna Trix, Inc., Houston, TX (US);
MD Anderson Cancer Center, Houston, TX (US);
Frank Tufaro, Rancho Santa Fe, CA (US);
Charles Conrad, Spring, TX (US);
Juan Fueyo-Margareto, Houston, TX (US);
Frederick Lang, Jr., Houston, TX (US);
Candelaria Gomez-Manzano, Houston, TX (US);
W. K. Alfred Yung, Houston, TX (US);
Amy Heimberger, Houston, TX (US);
DNATRIX, INC., Houston, TX (US);
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Austin, TX (US);
Abstract
The invention disclosed herein describes biomarkers useful for prognosis, selection and monitoring of oncolytic virus therapy for patients with various types of cancer. In particular, the present invention provides identification of proteins whose expression patterns are strongly predictive of the outcome of oncolytic virus therapy in a patient with cancer. The present invention provides a method for identifying and selecting cancer patients who are likely to be non-responsive to onocolytic virus therapy. These patients can be co-administered an agent that stimulates a cell-mediated immune response in the patient with the oncolytic virus or can be administered a therapy other than oncolytic virus therapy.