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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10238633 B1

PDFFull Text
Date of Patent:
Mar. 26, 2019

Filed:

Jun. 06, 2017

Methods for treating pulmonary emphysema using substituted 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin c

Applicant:

Boehringer Ingelheim International Gmbh, Ingelheim am Rhein, DE;

Inventors:

Ralf Anderskewitz, Laupheim, DE;

Florian Binder, Maselheim, DE;

Matthias Grauert, Biberach an der Riss, DE;

Marc Grundl, Biberach an der Riss, DE;

Peter Wilhelm Haebel, Mittelbiberach, DE;

Thorsten Oost, Biberach an der Riss, DE;

Alexander Pautsch, Biberach an der Riss, DE;

Stefan Peters, Biberach an der Riss, DE;

Viktor Vintonyak, Warthausen, DE;

Assignee:

Boehringer Ingelheim International GmbH, Ingelheim am Rhein, DE;

Attorney:

Philip I. Datlow

Primary Examiner:

Niloofar Rahmani

Int. Cl.
CPC ...
A61K 31/403 (2006.01); A61K 31/5383 (2006.01); C07D 209/52 (2006.01); A61K 31/4035 (2006.01); A61K 31/4045 (2006.01); A61K 31/4155 (2006.01); A61K 31/4192 (2006.01); A61K 31/438 (2006.01); A61K 31/496 (2006.01); A61K 31/551 (2006.01); A61K 45/06 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 403/14 (2006.01); C07D 405/12 (2006.01); C07D 487/10 (2006.01); C07D 498/04 (2006.01); C07D 471/08 (2006.01); A61K 31/397 (2006.01); A61K 31/404 (2006.01); A61K 31/416 (2006.01); A61K 31/473 (2006.01); C07D 401/10 (2006.01); C07D 409/12 (2006.01); C07D 413/14 (2006.01); C07D 417/12 (2006.01); A61K 31/423 (2006.01);
U.S. Cl.
CPC ...
A61K 31/403 (2013.01); A61K 31/397 (2013.01); A61K 31/404 (2013.01); A61K 31/4035 (2013.01); A61K 31/4045 (2013.01); A61K 31/416 (2013.01); A61K 31/4155 (2013.01); A61K 31/4192 (2013.01); A61K 31/423 (2013.01); A61K 31/438 (2013.01); A61K 31/473 (2013.01); A61K 31/496 (2013.01); A61K 31/5383 (2013.01); A61K 31/551 (2013.01); A61K 45/06 (2013.01); C07D 209/52 (2013.01); C07D 401/10 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 405/12 (2013.01); C07D 409/12 (2013.01); C07D 413/14 (2013.01); C07D 417/12 (2013.01); C07D 471/08 (2013.01); C07D 487/10 (2013.01); C07D 498/04 (2013.01); Y02A 50/409 (2018.01);
Abstract

This invention relates to 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.

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