The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 26, 2019
Filed:
Jun. 05, 2015
Academia Sinica, Taipei, TW;
Lie-Fen Shyur, Taipei, TW;
Kuo-Hsiung Lee, Chapel Hill, NC (US);
Kyoko Nakagawa-Goto, Ishikawa, JP;
Jia-Hua Feng, Taipei, TW;
Jo-Yu Chen, New Taipei, TW;
Wai-Leng Lee, Taichung, TW;
Yu-Ting Cheng, Taichung, TW;
Jing-Ying Huang, Taipei, TW;
Academia Sinica, Taipei, TW;
Abstract
A new class of sesquiterpene derivative useful for treating cancerous and inflammatory diseases are disclosed. These deoxyelephantopin derivatives are effective in suppressing proliferation, migration, mobility, invasion, growth, and/or metastasis of cancer cells in a patient, or useful for enhancing an anti-proliferative effect of another anti-cancer drug on cancer cells when treating a patient, or for sensitizing and/or enhancing an anti-cancer effect of a gluthathione synthesis blocker on inhibition of triple negative breast cancer cell activity, or for treatment and/or prophylaxis of lipopolysaccharide-stimulated inflammatory response in a patient, or for all of the above. Also disclosed are methods of preparing the deoxyelephantopin derivatives.