The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 26, 2019

Filed:

Jun. 15, 2017
Applicant:

Board of Trustees of the University of Arkansas, Little Rock, AR (US);

Inventor:

Alexandru S. Biris, Little Rock, AR (US);

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61L 27/36 (2006.01); A61L 27/54 (2006.01); A61L 27/58 (2006.01); A61F 2/08 (2006.01); A61F 2/28 (2006.01); B32B 37/24 (2006.01); B32B 37/26 (2006.01); B32B 38/00 (2006.01); A61L 27/38 (2006.01); A61L 27/44 (2006.01); A61L 27/46 (2006.01); A61L 27/50 (2006.01); A61L 27/56 (2006.01); A61L 27/34 (2006.01);
U.S. Cl.
CPC ...
A61F 2/28 (2013.01); A61F 2/08 (2013.01); A61L 27/34 (2013.01); A61L 27/365 (2013.01); A61L 27/3608 (2013.01); A61L 27/38 (2013.01); A61L 27/44 (2013.01); A61L 27/46 (2013.01); A61L 27/50 (2013.01); A61L 27/54 (2013.01); A61L 27/56 (2013.01); A61L 27/58 (2013.01); B32B 37/24 (2013.01); B32B 37/26 (2013.01); B32B 38/0004 (2013.01); A61F 2002/0894 (2013.01); A61F 2002/2825 (2013.01); A61F 2002/2835 (2013.01); A61L 2300/252 (2013.01); A61L 2300/254 (2013.01); A61L 2300/412 (2013.01); A61L 2300/414 (2013.01); A61L 2300/64 (2013.01); A61L 2400/12 (2013.01); A61L 2430/02 (2013.01); B32B 2037/243 (2013.01); B32B 2307/7163 (2013.01); B32B 2317/00 (2013.01); B32B 2323/04 (2013.01); B32B 2333/04 (2013.01); B32B 2375/00 (2013.01); B32B 2386/00 (2013.01); Y10T 156/1062 (2015.01); Y10T 156/1074 (2015.01);
Abstract

A biocompatible structure includes one or more base structures for regeneration of different tissues. Each base structure includes alternately stacked polymer layers and spacer layers. The polymer layer includes a polymer and tissue forming nanoparticles. The polymer includes polyurethane. The tissue forming nanoparticles includes hydroxypatites (HAP) nanoparticles, polymeric nanoparticles, or nanofibers. The spacer layer includes bone particles, polymeric nanoparticles, or nanofibers. The weight percentage of tissue forming nanoparticles to the polymer in the polymer layer in one base structure is different from that in the other base structures. A method of producing the biocompatible structure includes forming multiple base structures stacked together, coating the stacked multiple base structures, and plasma treating the coated structure.


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