The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 19, 2019
Filed:
Aug. 26, 2014
Applicant:
The University of Tokyo, Tokyo, JP;
Inventor:
Hiroaki Suga, Tokyo, JP;
Assignee:
The University of Tokyo, Tokyo, JP;
Primary Examiner:
Int. Cl.
CPC ...
C07K 7/64 (2006.01); G01N 33/68 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01); C12P 21/02 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6845 (2013.01); C07K 7/06 (2013.01); C07K 7/08 (2013.01); C07K 7/64 (2013.01); C12P 21/02 (2013.01); G01N 2500/04 (2013.01);
Abstract
An object of the present invention is to provide a peptide excellent in resistance against metabolism, having a stable structure in vivo, and capable of penetrating a cell membrane and reaching in cells. The present invention provides a macrocyclic peptide having a macrocyclic structure comprised of four or more amino acids. At least two amino acids not adjacent to each other have a hydrophobic side chain and the hydrophobic side chains interact with each other inside the ring of the macrocyclic peptide in a hydrophilic environment.