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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10233453 B1

PDFFull Text
Date of Patent:
Mar. 19, 2019

Filed:

Nov. 02, 2017

Generating targeted sequence diversity in fusion proteins

Applicant:

Innovative Targeting Solutions Inc., Vancouver, CA;

Inventors:

Michael Gallo, North Vancouver, CA;

Jaspal Singh Kang, Surrey, CA;

Craig Robin Pigott, Vancouver, CA;

Assignee:

INNOVATIVE TARGETING SOLUTIONS, British Columbia, CA;

Attorneys:

Thompson Coburn LLP

Charles P. Romano

Primary Examiner:

Michael D Burkhart

Int. Cl.
CPC ...
C12P 21/00 (2006.01); C12N 15/62 (2006.01); C07K 14/605 (2006.01); C07K 16/28 (2006.01); C07K 16/32 (2006.01); C12N 15/85 (2006.01); C07K 14/52 (2006.01); C07K 14/54 (2006.01); C07K 14/575 (2006.01); C07K 14/71 (2006.01); C07K 14/78 (2006.01); C07K 14/47 (2006.01); C07K 16/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/625 (2013.01); C07K 14/4723 (2013.01); C07K 14/522 (2013.01); C07K 14/5421 (2013.01); C07K 14/57563 (2013.01); C07K 14/605 (2013.01); C07K 14/71 (2013.01); C07K 14/78 (2013.01); C07K 16/00 (2013.01); C07K 16/2839 (2013.01); C07K 16/2866 (2013.01); C07K 16/2869 (2013.01); C07K 16/32 (2013.01); C12N 15/62 (2013.01); C12N 15/85 (2013.01); C07K 2317/565 (2013.01); C07K 2318/10 (2013.01); C07K 2319/00 (2013.01); C07K 2319/01 (2013.01); C07K 2319/03 (2013.01); C12N 2800/30 (2013.01);
Abstract

Methods of generating fusion protein variants are provided that comprise introducing sequence diversity at the junction region or regions in the fusion and allows for the generation of variants having a desired activity. Examples include immunoglobulins comprising a domain or polypeptide inserted into, or replacing, a CDR. Also provided are polynucleotides encoding a fusion protein and comprising two or more RSSs, and compositions and host cells comprising same, as well as fusion proteins variants produced by the described methods.

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