The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 19, 2019
Filed:
Jun. 10, 2016
Applicant:
Elwha Llc, Bellevue, WA (US);
Inventors:
Roderick A. Hyde, Redmond, WA (US);
Wayne R. Kindsvogel, Seattle, WA (US);
Gary L. McKnight, Bothell, WA (US);
Assignee:
Elwha LLC, Bellevue, WA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/10 (2006.01); A61K 38/00 (2006.01); C12N 5/0781 (2010.01); C12N 15/85 (2006.01); A61K 35/17 (2015.01); A61K 39/00 (2006.01); C07K 16/00 (2006.01); C07K 16/10 (2006.01); C07K 16/12 (2006.01); C07K 16/18 (2006.01); C07K 16/30 (2006.01); C07K 16/44 (2006.01); A61K 35/12 (2015.01);
U.S. Cl.
CPC ...
C12N 5/0635 (2013.01); A61K 35/17 (2013.01); A61K 39/00 (2013.01); C07K 16/00 (2013.01); C07K 16/109 (2013.01); C07K 16/1018 (2013.01); C07K 16/1271 (2013.01); C07K 16/18 (2013.01); C07K 16/3069 (2013.01); C07K 16/44 (2013.01); C12N 15/85 (2013.01); A61K 2035/124 (2013.01); A61K 2039/505 (2013.01); A61K 2039/5156 (2013.01); C07K 2317/14 (2013.01); C07K 2317/76 (2013.01); C12N 2510/00 (2013.01);
Abstract
Compositions and methods are disclosed herein for producing one or more immunoglobulins in an isolated cytotoxic B lymphocyte cell line. An isolated cell line includes an isolated B lymphocyte cell line capable of expressing at least one exogenously incorporated membrane immunoglobulin reactive to a first antigen and at least one endogenous secreted immunoglobulin reactive to a second antigen, and further capable of expressing at least one exogenously incorporated recombinant B cell receptor that signals for expression of cytotoxic effector molecules.