The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 19, 2019
Filed:
Mar. 21, 2015
Zhejiang University, Zhejiang, CN;
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, CN;
Xiaowu Dong, Zhejiang, CN;
Jia Li, Shanghai, CN;
Bo Yang, Zhejiang, CN;
Yongzhou Hu, Zhejiang, CN;
Yubo Zhou, Shanghai, CN;
Qinjie Weng, Zhejiang, CN;
Wenhu Zhan, Zhejiang, CN;
Lei Xu, Shanghai, CN;
Tao Liu, Zhejiang, CN;
Qiaojun He, Zhejiang, CN;
ZHEJIANG UNIVERSITY, Zhejiang, CN;
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES, Shanghai, CN;
Abstract
Disclosed are new substituted nitrogen-containing heterocyclic derivatives represented by formula (I) as AKT inhibitors, optical isomers, pharmaceutically acceptable salts or solvates thereof, wherein the definition of R1, R2, R3, R4, R5, R6, ring A, ring C, B, Q, Y, Z and m is shown in the description for details. In addition, medicaments comprising the derivatives as active components are also disclosed, which can be useful for treating proliferative diseases, such as cancer and inflammation, especially diseases relating to AKT kinase.