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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10233170 B1

PDFFull Text
Date of Patent:
Mar. 19, 2019

Filed:

Apr. 02, 2015

2,3-disubstituted pyridine compounds as tgf-beta inhibitors and methods of use

Applicant:

Rigel Pharmaceuticals, Inc., South San Francisco, CA (US);

Inventors:

Rajinder Singh, Belmont, CA (US);

Somasekhar Bhamidipati, Foster City, CA (US);

Pingyu Ding, Foster City, CA (US);

Donald Payan, Hillsborough, CA (US);

Marina Gelman, San Francisco, CA (US);

Todd Kinsella, Redwood City, CA (US);

Assignee:

Rigel Pharmaceuticals, Inc., South San Francisco, CA (US);

Attorneys:

McDonnell Boehnen Hulbert & Berghoff LLP

Travis Young

Primary Examiner:

Kortney L Klinkel

Assistant Examiner:

Ibrahim D Bori

Int. Cl.
CPC ...
C07D 401/04 (2006.01); A61K 31/519 (2006.01); A61K 45/06 (2006.01); A61K 31/4439 (2006.01); C07D 405/14 (2006.01); C07F 7/08 (2006.01); C07K 16/28 (2006.01); A61K 31/444 (2006.01); A61K 31/517 (2006.01); A61K 31/695 (2006.01); A61K 31/5377 (2006.01); A61K 31/635 (2006.01); A61K 39/395 (2006.01); C07D 401/14 (2006.01); C07D 487/04 (2006.01); C07D 471/04 (2006.01); C07D 417/14 (2006.01); C07D 417/04 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07D 401/04 (2013.01); A61K 31/444 (2013.01); A61K 31/4439 (2013.01); A61K 31/517 (2013.01); A61K 31/519 (2013.01); A61K 31/5377 (2013.01); A61K 31/635 (2013.01); A61K 31/695 (2013.01); A61K 39/39541 (2013.01); A61K 45/06 (2013.01); C07D 401/14 (2013.01); C07D 405/14 (2013.01); C07D 417/04 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07F 7/0812 (2013.01); C07K 16/2818 (2013.01); A61K 2039/505 (2013.01);
Abstract

The invention described herein comprises compounds of formula (IV) and a method of treating cancer comprising administering to a subject having cancer one of the compounds in conjunction with another therapeutic treatment of cancer. The compounds (IV) inhibit signaling by a member of the TGF-β superfamily such as Nodal or Activin.

Find Patent Forward Citations

Singh, Rajinder. (2019). 2,3-disubstituted pyridine compounds as tgf-beta inhibitors and methods of use (U.S. Patent No. 10233170). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10233170

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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