The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 19, 2019
Filed:
Jun. 17, 2015
Centre National DE LA Recherche Scientifique (Cnrs), Paris, FR;
Pascal Collin, Buc, FR;
Bernard Delpech, Clamart, FR;
Joanna Bakala, Paris, FR;
Bogdan Iorga, Antony, FR;
Yves-Michel Frapart-Jannuad, Ecury sur Coole, FR;
Fabienne Peyrot, Ivry, FR;
Franck Pelissier, Gif S/Yvette, FR;
Maria Conception Achab, Gif S/Yvette, FR;
Abstract
The present invention relates to a 3-aryl-4 catechol-pyrrole-n-propanol compound and the derivatives thereof having General Formula (I), wherein:—Ris an aryl group, particularly a phenyl, optionally substituted by one or more (C-C)alkyl groups, one or more halogens, one or more —OH, —CN or CFgroups, or a combination of same, and—Ris a (C-C)alkyl group, a hydroxy(C-C)alkyl group, a (C-C)alcoxy(C-C)alkyl group, or a pharmaceutically acceptable hydrate or solvate of same. The invention also relates to the methods for preparing said compound and derivatives, to the pharmaceutical compositions containing same, and to the use of same as a drug or in the form of a prodrug converted via dimerization, particularly via oxidative coupling in the presence of a superoxide anion, in the treatment of cancer and diseases related to excessive angiogenesis.