The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 19, 2019
Filed:
Nov. 06, 2014
The Charles Stark Draper Laboratory, Inc., Cambridge, MA (US);
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Guillermo Garcia-Cardena, Cambridge, MA (US);
Peter Mack, Chapel Hill, NC (US);
Jeffrey T. Borenstein, Newton, MA (US);
Ahmad S. Khalil, Boston, MA (US);
Eli J. Weinberg, Needham, MA (US);
Jason O. Fiering, Boston, MA (US);
Ernest S. Kim, Cambridge, MA (US);
William J. Adams, Jr., Cambridge, MA (US);
Mitchell Hansberry, Southborough, MA (US);
Stephen Bellio, Newton, MA (US);
The Charles Stark Draper Laboratory, Inc., Cambridge, MA (US);
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Abstract
The systems and methods described herein relate to a high-throughput flow apparatus. The apparatus is used with an array of wells, and is configured to impart a predetermined shear stress on cells cultured within each of the wells of the array of wells. The apparatus includes a plurality of mechanical tips. The plurality of mechanical tips each includes a head with a hemispheroid shape. The apparatus also includes a motor associated with at least one of plurality of mechanical tips. The motor is configured to drive the plurality of mechanical tips to impart the shear stress pattern in each of the wells.