The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 19, 2019
Filed:
Sep. 25, 2015
Applicants:
Duke University, Durham, NC (US);
Los Alamos National Security, Llc, Los Alamos, NM (US);
Inventors:
Barton F. Haynes, Durham, NC (US);
Hua-Xin Liao, Durham, NC (US);
Bette T. Korber, Los Alamos, NM (US);
Peter T. Hraber, Los Alamos, NM (US);
Assignees:
DUKE UNIVERSITY, Durham, NC (US);
LOS ALAMOS NATIONAL SECURITY, LLC, Los Alamos, NM (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); C07K 14/005 (2006.01); A61K 39/12 (2006.01); A61K 39/21 (2006.01); C12N 7/00 (2006.01); A61K 31/4706 (2006.01); A61K 39/395 (2006.01); A61K 47/48 (2006.01); C07K 14/705 (2006.01);
U.S. Cl.
CPC ...
A61K 39/21 (2013.01); A61K 31/4706 (2013.01); A61K 39/12 (2013.01); A61K 39/3955 (2013.01); A61K 47/4833 (2013.01); A61K 47/48276 (2013.01); A61K 47/48338 (2013.01); A61K 47/48815 (2013.01); C07K 14/70578 (2013.01); C12N 7/00 (2013.01); A61K 2039/505 (2013.01); A61K 2039/545 (2013.01); A61K 2039/6018 (2013.01); A61K 2039/627 (2013.01); C07K 2319/70 (2013.01); C12N 2740/16134 (2013.01);
Abstract
In certain aspects the invention provides a selection of HIV-1 envelopes suitable for use as immunogens, and methods of using these immunogens to induce neutralizing antibodies. In certain embodiments, the immunogens are designed to trimerize. In other embodiments, the immunogens comprise an immune modulating component.