The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 19, 2019
Filed:
Jun. 05, 2017
Pieris Pharmaceuticals Gmbh, Freising, DE;
Astrazeneca Ab, Sodertalje, SE;
Andreas Hohlbaum, Paunzhausen, DE;
Alexandra Baehre, Farum, DK;
Gabriele Matschiner, Munich, DE;
Stefan Trentmann, Allershausen, DE;
Klaus Kirchfeld, Petershausen, DE;
Hans-Juergen Christian, Moosburg, DE;
PIERIS PHARMACEUTICALS GMBH, Freising, DE;
ASTRAZENECA AB, Sodertalje, SE;
Abstract
The present invention relates to novel muteins derived from human tear lipocalin, which bind to IL 4 receptor alpha. The sequences of the muteins comprise particular combinations of amino acids. In particular a mutated amino acid residue is present at any one or more of the sequence positions 27, 28 30, 31, 33, 53, 57, 61, 64, 66, 80, 83, 104-106 and 108 of the linear polypeptide sequence of the mature human tear lipocalin. A mutated amino acid residue is also present at any 2 or more of the sequence positions 26, 32, 34, 55, 56, 58 and 63 of the linear polypeptide sequence of the mature human tear lipocalin. The invention also provides a corresponding nucleic acid molecule encoding such a mutein and a method for producing such a mutein and its encoding nucleic acid molecule.