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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10231996 B1

PDFFull Text
Date of Patent:
Mar. 19, 2019

Filed:

Feb. 22, 2016

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Applicant:

Council of Scientific & Industrial Research, New Delhi, IN;

Inventors:

Sudip Mukherjee, Hyderabad, IN;

Chitta Ranjan Patra, Hyderabad, IN;

Assignee:

COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH, New Delhi, IN;

Attorney:

Banner & Witcoff, Ltd.

Primary Examiner:

Anna R Falkowitz

Int. Cl.
CPC ...
A61K 33/38 (2006.01); A01N 59/16 (2006.01); A01N 25/26 (2006.01); A61K 9/51 (2006.01); A01N 25/28 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61K 33/38 (2013.01); A01N 25/28 (2013.01); A01N 59/16 (2013.01); A61K 9/5138 (2013.01); A61K 9/5146 (2013.01); A61K 9/5192 (2013.01); A61K 9/0019 (2013.01);
Abstract

The present invention relates to highly biocompatible or nontoxic PVP (poly(n-vinyl-2-pyrrolidone) coated silver prussian blue nanoparticles (SPB-NPS: Ag[Fe(CN)] where PVP acts as stabilizing or capping agent. The as-synthesized nanoparticles (SPB-NPs) have been thoroughly characterized by several analytical tools. The SPB-NPs are highly stable for more than two weeks towards different physiological buffers or solutions with different pH (pH=6, −7.4 & −8). These nanoparticles (SPB-NPs) exhibit biocompatibility towards various normal cells (HUVEC, CHO, & ECV304) but show significant inhibition of proliferation of different cancer cells in vitro and tumor growth in C57/BL6/J mice model (aggressive murine melanoma cancer model: B16F10). Additionally, the SPB-NPs show excellent antibacterial activity towards gram-negative () and gram-positive () bacteria. Consider all results together; these biocompatible SPB-NPs would be potentially useful for the development towards alternative anti-cancer agent as well as anti-bacterial agent in near future.

Find Patent Forward Citations

Mukherjee, Sudip. (2019). [object object] (U.S. Patent No. 10231996). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10231996

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