The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 19, 2019

Filed:

Oct. 31, 2014
Applicant:

Vertex Pharmaceuticals Incorporated, Boston, MA (US);

Inventors:

Kelly Ann Swinney, Boston, MA (US);

Patricia Nell Hurter, Harvard, MA (US);

David E. Nadig, Dorchester, MA (US);

David Smith, Newton, MA (US);

Vance Hayden Thomas, Duxbury, MA (US);

Martin Paul Warman, Hingham, MA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/14 (2006.01); A61K 9/16 (2006.01); A61K 9/20 (2006.01); A61K 31/47 (2006.01); A61K 45/06 (2006.01); A61K 31/443 (2006.01);
U.S. Cl.
CPC ...
A61K 9/2095 (2013.01); A61K 9/1652 (2013.01); A61K 9/1682 (2013.01); A61K 9/1694 (2013.01); A61K 9/2027 (2013.01); A61K 9/2054 (2013.01); A61K 9/2077 (2013.01); A61K 31/443 (2013.01); A61K 31/47 (2013.01); A61K 45/06 (2013.01); A61K 9/146 (2013.01);
Abstract

Processes of preparing pharmaceutical compositions comprising 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-1H-quinoline-3-carboxamide (Compound 2), methods of treating, lessening the severity of or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of administering, and kits thereof are disclosed.


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