The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 19, 2019
Filed:
Nov. 17, 2016
The Charles Stark Draper Laboratory, Inc., Cambridge, MA (US);
The General Hospital Corporation, Boston, MA (US);
Joseph P. Vacanti, Boston, MA (US);
Young-Moon M. Shin, Somerville, MA (US);
Jennifer Ogilvie, San Francisco, CA (US);
Alexander Sevy, Houston, TX (US);
Tomoyuki Maemura, Boston, MA (US);
Osamu Ishii, Arlington, MA (US);
Mohammad R. Kaazempur-Mofrad, Cambridge, MA (US);
Jeffrey T. Borenstein, Holliston, MA (US);
Kevin R. King, Western Springs, IL (US);
Chiao-Chun Wang, Baltimore, MD (US);
Eli Weinberg, Needham, MA (US);
The Charles Stark Draper Laboratory, Inc., Cambridge, MA (US);
The General Hospital Corporation, Boston, MA (US);
Abstract
Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick, structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided.