The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 19, 2019

Filed:

Mar. 14, 2014
Applicant:

The Regents of the University of California, Oakland, CA (US);

Inventors:

Zhongping Chen, Irvine, CA (US);

Wenjuan Qi, Irvine, CA (US);

Rui Li, Irvine, CA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61B 8/00 (2006.01); A61B 8/08 (2006.01); A61B 5/00 (2006.01); A61B 5/02 (2006.01); A61B 8/12 (2006.01);
U.S. Cl.
CPC ...
A61B 8/485 (2013.01); A61B 5/0035 (2013.01); A61B 5/0066 (2013.01); A61B 5/02007 (2013.01); A61B 8/12 (2013.01); A61B 8/445 (2013.01); A61B 8/4416 (2013.01); A61B 8/5261 (2013.01);
Abstract

An integrated intraluminal imaging system includes an optical coherence tomography interferometer (OCT), an ultrasound subsystem (US) and a phase resolved acoustic radiation force optical coherence elastography subsystem (PR-RAF-OCE). The steps include performing OCT to generate a returned optical signal, performing US imaging to generate a returned ultrasound signal, performing PRARF-OCE to generate a returned PR-ARF-OCE signal by generating a amplitude modulated ultrasound beam or chirped amplitude modulated ultrasound beam to frequency sweep the acoustic radiation force, measuring the ARF induced tissue displacement using phase resolved OCT, and the frequency dependence of the PR-ARF-OCE signal, processing the returned optical signal, the returned ultrasound signal and the measured frequency dependence of the returned PR-ARF-OCE optical coherence elastographic signal to quantitatively measure the mechanical properties of the identified tissues with both spectral and spatial resolution using enhanced materials response at mechanically resonant frequencies.


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