The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 12, 2019
Filed:
Apr. 14, 2016
Pion Inc., Billerica, MA (US);
Ajit S. Narang, Monmouth Junction, NJ (US);
Dan Tang, Brooklyn, NY (US);
Scott P. Jennings, Bridgewater, NJ (US);
Neil Mathias, North Brunswick, NJ (US);
Konstantin L. Tsinman, Littleton, MA (US);
Deren J. Dohoda, Billerica, MA (US);
David A. Kwajewski, Wilbraham, MA (US);
Michael G. Kelly, Waltham, MA (US);
PION INC., Billerica, MA (US);
Abstract
An apparatus for the combined assessment of dissolution and permeability relies on a receiver chamber that is contained within a donor chamber. A membrane is provided between the two chambers. Measurements can be taken to determine solute amounts of a drug introduced in the donor chamber and amounts of permeated solute in the receiver chamber. Also described are techniques for the assessment of a dissolution rate and total amount of dissolved compound, together with their effect on absorption potential of a compound or a compound product as well as approaches for evaluating in vivo relevant differences between formulations of a compound through their effect on the absorption potential of the compound.