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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10227405 B1

PDFFull Text
Date of Patent:
Mar. 12, 2019

Filed:

Feb. 17, 2016

Methods of modulating the activity of adrenomedullin in a subject in need of regulation of fluid balance by administering an anti-adrenomedullin (adm) antibody or an anti-adm antibody fragment

Applicant:

Adrenomed Ag, Hennigsdorf, DE;

Inventor:

Andreas Bergmann, Berlin, DE;

Assignee:

ADRENOMED AG, Hannigsdorf, DE;

Attorneys:

Millen White Zelano and Branigan, PC

John Sopp

Primary Examiner:

Christine J Saoud

Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/26 (2006.01); G01N 33/68 (2006.01); A61K 31/137 (2006.01); A61K 9/00 (2006.01); A61K 9/08 (2006.01); A61K 9/19 (2006.01); A61K 45/06 (2006.01); A61P 31/00 (2006.01); A61P 9/00 (2006.01); A61P 13/12 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/26 (2013.01); A61K 9/0019 (2013.01); A61K 9/08 (2013.01); A61K 9/19 (2013.01); A61K 31/137 (2013.01); A61K 39/3955 (2013.01); A61K 45/06 (2013.01); A61P 9/00 (2018.01); A61P 13/12 (2018.01); A61P 31/00 (2018.01); G01N 33/6893 (2013.01); A61K 2039/505 (2013.01); C07K 2317/20 (2013.01); C07K 2317/21 (2013.01); C07K 2317/24 (2013.01); C07K 2317/34 (2013.01); C07K 2317/54 (2013.01); C07K 2317/55 (2013.01); C07K 2317/56 (2013.01); C07K 2317/622 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01); G01N 2800/52 (2013.01); G01N 2800/7095 (2013.01);
Abstract

Patients having a chronic or acute disease or acute condition, especially patients at the ICU (Intensive Care Unit) suffer from fluid imbalance. The present invention provides a medicament for regulating the fluid balance and/or improving the fluid balance of such patients. Subject matter of the present invention is an anti-Adrenomedullin (ADM) antibody or an anti-adrenomedullin antibody fragment or an anti-ADM non-Ig scaffold for regulating the fluid balance in a patient having a chronic or acute disease or acute condition. The present invention also provides a method for regulating the fluid balance in a patient having a chronic or acute disease or acute condition. Subject matter of the present invention is an anti-Adrenomedullin ADM antibody or anti-ADM non-Ig scaffold or an anti-adrenomedullin antibody fragment for use in therapy of a chronic or acute disease or acute condition of a patient for the regulation of fluid balance.

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