The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 12, 2019
Filed:
Apr. 06, 2016
Acceleron Pharma Inc., Cambridge, MA (US);
Ravindra Kumar, Acton, MA (US);
Asya Grinberg, Lexington, MA (US);
Dianne Sako, Medford, MA (US);
Robert Scott Pearsall, North Reading, MA (US);
Roselyne Castonguay, Watertown, MA (US);
Gang Li, Sudbury, MA (US);
Yossi Dagon, Framingham, MA (US);
John Knopf, Carlisle, MA (US);
ACCELERON PHARMA INC., Cambridge, MA (US);
Abstract
In certain aspects, the disclosure provides soluble heteromeric polypeptide complexes comprising an extracellular domain of an ALK7 receptor and an extracellular domain of ActRIIB. In certain aspects, these ALK7:ActRIIB heteromultimers are can be used to improve metabolic parameters in a patient in need thereof. In certain aspects, these ALK7:ActRIIB heteromultimers are can be used to treat or prevent one or more kidney-associated disease or condition in a patient in need thereof.