The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 12, 2019
Filed:
Jun. 13, 2014
President and Fellows of Harvard College, Cambridge, MA (US);
Gregory L. Verdine, Boston, MA (US);
Gerard Hilinski, Somerville, MA (US);
Rebecca Yue Liang, Cambridge, MA (US);
Yvonne Alice Nagel, Somerville, MA (US);
Minyun Zhou, Malden, MA (US);
PRESIDENT AND FELLOWS OF HARVARD COLLEGE, Cambridge, MA (US);
Abstract
Provided herein are stabilized α-CT polypeptides comprising an alpha-helical segment, and wherein the polypeptide is of Formula (I-1) or Formula (I-2): R—[X]—X—X—X—X—X—X—X—X—X—X—X—X—X—X—[X]—R(I-1) R—[X]—X—X—X—X—X—X—X—X—X—X—X—X—X—X—X—X—X—X—X—X—[X]—R(I-2) wherein the α-CT polypeptide binds to the insulin receptor, and wherein the α-CT polypeptide includes at least one staple (i.e. two cross-linked amino acids) and/or at least one stitch (i.e. three cross-linked amino acids). Further provided are insulin analogs including the stapled or stitched α-CT polypeptides, pharmaceutical compositions thereof, methods of use, e.g., methods of treating a diabetic condition or complications thereof.