The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 12, 2019
Filed:
Feb. 22, 2018
Ohara Pharmaceutical Co., Ltd., Koka-cho, Koka-shi, Shiga, JP;
Magoichi Sako, Shiga, JP;
Shinpei Sugiyama, Shiga, JP;
Ohara Pharmaceutical Co., Ltd., Shiga, JP;
Abstract
The present invention relates to a prodrug of 5-azacytidine or 2'-deoxy-5-azacytidine having remarkable stability against cytidine deaminase, a metabolic hydrolyzing enzyme in replacement of current injections (5-azacytidine or 2′-deoxy-5-azacytidine) which are clinically used as therapeutic agents for various myelomas including myelodysplastic syndrome. The present invention provides a compound represented by formula (1), or salt thereof, wherein, R is ORor a hydrogen atom, R, R, and Rare each independently hydrogen atom or silyl group represented by formula (2): wherein, R, R, and Rare each independently alkyl group which may have a substituent, aryl group which may have a substituent, or arylalkyl group which may have a substituent, with the provision that R, R, and Rare not hydrogen atom simultaneously.