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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10227343 B1

PDFFull Text
Date of Patent:
Mar. 12, 2019

Filed:

Feb. 01, 2016

Isoquiniline and napthalene-substituted compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction

Applicant:

Vanderbilt University, Nashville, TN (US);

Inventors:

P. Jeffrey Conn, Brentwood, TN (US);

Craig W. Lindsley, Brentwood, TN (US);

Colleen M. Niswender, Brentwood, TN (US);

Corey R. Hopkins, Nolensville, TN (US);

Joanne Bronson, Princeton, NJ (US);

Yong-Jin Wu, Princeton, NJ (US);

Kyle Emmitte, Nashville, TN (US);

Joe Panarese, Malden, MA (US);

Darren W. Engers, Nashville, TN (US);

Julie Engers, Nashville, TN (US);

Assignee:

Vanderbilt University, Nashville, TN (US);

Attorneys:

Stites & Harbison PLLC

Richard S. Meyers, Jr.

Primary Examiner:

Daniel R Carcanague

Int. Cl.
CPC ...
C07D 471/04 (2006.01); A61K 31/496 (2006.01); A61K 31/437 (2006.01); A61K 31/554 (2006.01); A61K 31/553 (2006.01); C07D 487/04 (2006.01); A61K 31/4985 (2006.01); A61K 31/4725 (2006.01); A61K 31/541 (2006.01); A61K 31/4745 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61K 31/502 (2006.01); C07D 401/12 (2006.01); A61K 31/4375 (2006.01); C07D 519/00 (2006.01); A61K 31/519 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 31/437 (2013.01); A61K 31/4375 (2013.01); A61K 31/4725 (2013.01); A61K 31/4745 (2013.01); A61K 31/496 (2013.01); A61K 31/4985 (2013.01); A61K 31/502 (2013.01); A61K 31/506 (2013.01); A61K 31/519 (2013.01); A61K 31/5377 (2013.01); A61K 31/541 (2013.01); A61K 31/553 (2013.01); A61K 31/554 (2013.01); A61K 45/06 (2013.01); C07D 401/12 (2013.01); C07D 487/04 (2013.01); C07D 519/00 (2013.01);
Abstract

Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.

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