The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 12, 2019
Filed:
Oct. 06, 2014
Universitetet I Oslo, Oslo, NO;
Pål Rongved, Oslo, NO;
Ove Alexander Høgmoen Åstrand, Oslo, NO;
Annette Bayer, Tromsø, NO;
Hanna-Kirsti Schrøder Leiros, Tromsø, NO;
Ørjan Samuelsen, Tromsø, NO;
Kine Susann Waade Edvardsen, Paradis, NO;
Zeeshan Muhammad, Tromsø, NO;
Universitetet | Oslo, Oslo, NO;
Abstract
Compounds according to formula I are provided:A-L-Bwherein A represents a lipophilic chelating moiety which is selective for Znions; L is a covalent bond or a linker; and B is a vector which is either a moiety capable of interacting with one or more biological structures found in a bacterium (preferably in a bacterial cell wall), for example a penicillin-binding protein such as a metallo-β-lactamase or DD-transferase, or a moiety capable of enhancing transport of the compound across a bacterial cell membrane. A method of treating and/or preventing a bacterial infection in a human or non-human mammal employing such compounds are also provided. In such a method, the compound of formula I may be administered in combination with (either simultaneously, separately, or sequentially) a β-lactam antibiotic.